Rhodopsin, upon activation by light, transduces the photon signal by activation of the G‐protein, transducin. The well‐studied rhodopsin/transducin system serves as a model for the understanding of signal transduction by the large class of G‐protein‐coupled receptors. The interactive form of rhodopsin, R*, is conformationally similar or identical to rhodopsin's photolysis intermediate Metarhodopsin II (MII). Formation of MII requires deprotonation of rhodopsin's protonated Schiff base which appears to facilitate some opening of the rhodopsin structure. This allows a change in conformation at (...) rhodopsin's cytoplasmic surface that provides binding sites for transducin. Rhodopsin's 2nd, 3rd and putative 4th cytoplasmic loops bind transducin at sites including transducin's 5 kDa carboxyl‐terminal region. Site‐specific mutagenesis of rhodopsin is being used to distinguish sites on rhodopsin's surface that are important in binding transducin from those that function in activating transducin. These observations are consistent with and extend studies on the action of other G‐protein‐coupled receptors and their interactions with their respective G proteins. (shrink)

Darcy's law is a phenomenological relationship for fluid flow rate that finds one of its principle applications in hydrology. Theoretical hydrologists rely upon a multiplicity of conceptual models to carry out approximate derivations of Darcy's law. These derivations provide structural explanations of the law; they require the application of fundamental principles, such as conservation of momentum, to idealized models of the porous media within which the flow occurs. In practice, recognition of the idealized conditions incorporated into models facilitates the empirical (...) clarification of the domain within which the law remains accurate. Structural explanations also contribute to the physical interpretation of phenomenological parameters. (shrink)

The belated but formal acknowledgment of medical errors and their impact has been well documented. Curiously, the topic of management or executive mistakes in healthcare is not raised in professional meetings nor, until recently, addressed by an article in health administration journals.

The following description is based upon an actual case in which a patient initiated legal action after suffering a complication subsequent to an invasive diagnostic procedure performed by a senior fellow. Named as codefendants were the senior fellow, attending physician, and the hospital. Because any hospital with house staff is potentially vulnerable to similar litigation, Ethics Committees at Work is addressing the questions raised by this dilemma.

Our ethics committee is revising the organization's policy on forgoing life-sustaining treatment. The current policy now includes the statement, “When life-sustaining treatment is forgone, supportive care will be provided to relieve pain and ensure the patient's comfort, unless the patient or surrogate refuses those measures.” Is it reasonable, however, for the surrogate to have the authority to refuse consent for pain medication and/or other supportive care?

Like some ethical dilemmas, this question has an obvious answer that may not be right. On first reflection, it seems entirely unreasonable and inappropriate to expect staff members to withhold supportive care. Legally, a designated surrogate has the authority to refuse pain medication on the patient's behalf, but is it ethically defensible? A patient lacking decisionmaking capacity is crying out in pain; can we really imagine just closing the door? What do we say to other patients, visitors, and staff members, (...) such as physicians, nurses, housekeepers, and dietary workers, who might hear the patient? Do we place a sign on the door, one noting that the surrogate has refused, on behalf of the patient, to authorize the administration of pain medication and that the hospital or nursing home must comply with the surrogate's decision? (shrink)

Le sens désigne la subjectivité du sujet. II n’est pas seulement une disposition effective de l'âme, de lui il у a aussi un savoir. Le savoir du sens appartient à la connaissance, et il s’oriente vers une verité ou exactitude qui lui sont particulières. La connaissance de la chose et la connaissance du sens se distinguent par le sens différent qui anime et forme l'une et l'autre. La connaissance de la chose s’accomplit par la transcendance, par l’addition de l'autre à (...) la conscience qui se connaît elle-même. La connaissance du sens s’accomplit comme « Introscendance concentrique » ; eile veut approfondir le sens à chercher, en l’exposant dans l’image des expériences diverses, que le sens rend possible. La connaissance de la chose et celle du sens tombent sous deux logiques de pôle opposé ; ces deux logiques répondent à la différence corrélative de l’altérité des choses et de l’identité du sens. (shrink)

Excerpt from Empfindung und Vorstellung: Ein Beitrag zur Klarung Psychologischer Grundbegriffe Vor kurzem erschien eine Abhandlung von Carl Stumpf uber Empfindung und Vorstellung, welche auf Grund feinfuhliger Selbstbeobachtungen und unter Berucksichtigung der grossen einschlagigen Literatur in die vielen Winkel und Dunkelheiten dieses Problems der deskriptiven Psychologie hineinleuchtet. Unter sorgfaltiger Analyse der von den verschiedenen Beobachtern gegebenen Beschreibungen und scharfsinniger Untersuchung der logischen Durchfuhrbarkeit jeder einzelnen der bisher ausgesprochenen Auffassungen versucht diese Abhandlung die Frage zu klaren, worin der wesentliche Unterschied beider (...) Erlebnisarten besteht. Als Ergebnis gelangt Stumpf in der Hauptsache zu einer Rechtfertigung der altuberlieferten Auffassung, nach der ein "spezifischer" Unterschied zwischen Empfindung und Vorstellung nicht vorliegt, sich die Vorstellungen vielmehr vor allem durch ihre geringere Intensitat von den Empfindungen unter-scheiden. Ausser an Intensitat fehlt es den Vorstellungen im Gegensatz zu den Empfindungen an Fulle und Bestandigkeit, ferner sind sie dadurch charakterisiert, dass sie willkurlich leichter modifizierbar sind, dass ihnen gegenuber der Glaube an die Realitat fur das erlebende Bewusstsein einer Rechtfertigung bedarf, und dass sie durchschnittlich schwachere Gefuhlswirkungen mit sich fuhren. Vorstellungen stellen sich so den Empfindungen gegenuber als "Erscheinungen zweiter Ordnung" dar: in dem Inhalt der Erlebnisse, nicht in den Akten des Erlebens, ist ihre Verschiedenheit zu suchen. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.". (shrink)

Disease radically changes the life of many people and satisfies formal criteria for being a transformative experience. According to the influential philosophy of Paul, transformative experiences undermine traditional criteria for rational decision-making. Thus, the transformative experience of disease can challenge basic principles and rules in medical ethics, such as patient autonomy and informed consent. This article applies Paul’s theory of transformative experience and its expansion by Carel and Kidd to investigate the implications for medical ethics. It leads to (...) the very uncomfortable conclusion that disease involves transformative experiences in ways that can reduce people’s rational decision-making ability and undermine the basic principle of respect for autonomy and the moral rule of informed consent. While such cases are limited, they are crucial for medical ethics and health policy and deserve more attention and further scrutiny. (shrink)

Theological attention to the Catholic doctrine of original sin has a history that extends from the letters of Saint Paul through the Council of Trent and Pius XII’s 1950 encyclical, Humani generis. The doctrine has traditionally been articulated through the Genesis narrative of Adam and Eve as the first human beings from whom all others descend, an account known as monogenism. In the course of the nineteenth century, scientific research into human origins increasingly relied upon polygenism, the descent of (...) humanity from non-human ancestors through a transitional population. Subsequent Catholic engagement with evolution included resistance to polygenism from the Vatican due to a perceived conflict with the doctrine of original sin. Humani generis included a prohibition that remains in place today in spite of widespread de facto acceptance of polygenism among theologians. Understanding the origin and persistence of this disparity stands to benefit from comparison to a corresponding ambivalence toward the sixteenth century Copernican hypothesis of a moving earth, only conclusively resolved in 1992. In Part I of this essay I introduce this historical comparison and describe the origins of monogenism and polygenism terminology in nineteenth century debate over the unity of the human race. I then describe the conceptual changes that transpired during the first half of the twentieth century and the resulting role of polygenism in the nouvelle théologie of the decade prior to Humani generis. Subsequent developments and implications follow in Part II. (shrink)

In this chapter a new problem about rule-following is outlined, one that is distinct both from Kripke’s and Wright’s versions of the problem. This new problem cannot be correctly responsed to, as Kripke’s can, by invoking Wright’s Intentional Account of rule-following. The upshot might be called, following Kant, an antinomy of pure reason: we both must — and cannot — make sense of someone’s following a rule. The chapter explores various ways out of this antinomy without here endorsing any of (...) them. (shrink)

In the latest edition of their popular overview text, Erickson and Murphy continue to provide a comprehensive, affordable, and accessible introduction to anthropological theory from antiquity to the present.

Should a principle of charity be applied to the interpretation of the colour concepts exercised in visual experience? We think not. We shall argue, for one thing, that the grounds for applying a principle of charity are lacking in the case of colour concepts. More importantly, we shall argue that attempts at giving the experience of colour a charitable interpretation either fail to respect obvious features of that experience or fail to interpret it charitably, after all. Charity to visual experience (...) is therefore no motive for resisting the natural, Galilean response to a scientific understanding of light and vision. The best interpretation of colour experience ends up convicting it of widespread and systematic error. (shrink)

These essays examine the ways in which the consideration of ethical questions is shaped by the structures of knowledge and communication at work in clinical ...

This paper argues that, given a certain apparently inevitable thesis about content, we could not know our own minds. The thesis is that the content of a thought is determined by its relational properties.

The paper asks under what conditions deductive reasoning transmits justification from its premises to its conclusion. It argues that both standard externalist and standard internalist accounts of this phenomenon fail. The nature of this failure is taken to indicate the way forward: basic forms of deductive reasoning must justify by being instances of 'blind but blameless' reasoning. Finally, the paper explores the suggestion that an inferentialist account of the logical constants can help explain how such reasoning is possible.

This volume presents a series of influential essays by Paul Boghossian on the theory of content and on its relation to the phenomenon of a priori knowledge. The essays are organized under four headings: the nature of content; content and self-knowledge; knowledge, content, and the a priori; and colour concepts.

It is very common these days to come across the claim that the notions of mental content and linguistic meaning are normative notions. In the work of many philosophers, it plays a pivotal role. Saul Kripke made it the centerpiece of his influential discussion of Wittgenstein’s treatment of rulefollowing and private language; he used it to argue that the notions of meaning and content cannot be understood in naturalistic terms. Kripke’s formulations tend to be in terms of the notion of (...) linguistic meaning, but his argumentative strategy makes it clear that he holds both versions of the claim.... (shrink)

According to a very natural picture of rational belief, we aim to believe only what is true. However, as Bernard Williams used to say, the world does not just inscribe itself onto our minds. Rather, we have to try to figure out what is true from the evidence available to us. To do this, we rely on a set of epistemic rules that tell us in some general way what it would be most rational to believe under various epistemic circumstances. (...) We reason about what to believe; and we do so by relying on a set of rules.... (shrink)

An irrealist conception of a given region of discourse is the view that no real properties answer to the central predicates of the region in question. Any such conception emerges, invariably, as the result of the interaction of two forces. An account of the meaning of the central predicates, along with a conception of the sorts of property the world may contain, conspire to show that, if the predicates of the region are taken to express properties, their extensions would have (...) to be deemed uniformly empty. The question then becomes whether the predicates are best understood as expressing properties, and hence as founded on error, or whether they ought to be understood along non-factualist lines.z Historically, irrealist models were developed primarily in connection with evaluative discourse, although as physicalism has flourished and as reductionist programs have failed, their application has been extended to many other domains. Indeed, it is one of the more influential suggestions in contemporary philosophy of mind that they apply even to ordinary belief/desire psychology. A correct understanding of the semantics and metaphysics of content-based psychology leaves us, so the proponents of the in-. (shrink)

Compatibilism combines an externalist view of mental content with a doctrine of privileged self‐knowledge. The essay presents a reductio of compatibilism by arguing that if compatibilism were true, we would be in a position to know certain facts about the world a priori, facts that no one can reasonably believe are knowable a priori. Whether this should be taken to cast doubt on externalism or privileged self‐knowledge is not discussed. Consideration is given to the ’empty case’—the case in which a (...) thinker expresses what he takes to be a genuine thought concerning a natural kind but where there is in fact no relevant natural kind, so that the putative natural kind term fails to refer. It is argued that, in such a case, on an externalist conception of natural kind terms, the thinker is deluded in taking himself to be expressing a complete thought, and that such delusions are not compatible with privileged self‐knowledge. (shrink)

The dispute between realists about color and anti-realists is actually a dispute about the nature of color properties. The disputants do not disagree over what material objects are like. Rather, they disagree over whether any of the uncontroversial facts about material objects--their powers to cause visual experiences, their dispositions to reflect incident light, their atomic makeup, and so on--amount to their having colors. The disagreement is thus about which properties colors are and, in particular, whether colors are any of the (...) properties in a particular set that is acknowledged on both sides to exhaust the properties of material objects. In a previous paper we discussed at length one attempt to identify colors with particular properties of material objects--namely, with their dispositions to cause visual experiences. Here we shall discuss a different and perhaps more influential version of realism, which says that the colors of material objects are microphysical properties of their surfaces. We shall call this theory physicalism about color (physicalism, for short). In order to evaluate this theory, however, we shall first have to clarify some methodological issues. Our hope is that we can bring some further clarity to the question of color realism, whether or not we succeed in our critique of the physicalists' answer. (shrink)

The paper is a defense of the project of explaining the a priori via the notion of meaning or concept possession. It responds to certain objections that have been made to this project—in particular, that there can be no epistemically analytic sentences that are not also metaphysically analytic, and that the notion of implicit definition cannot explain a priori entitlement. The paper goes on to distinguish between two different ways in which facts about meaning might generate facts about entitlement—inferential and (...) constitutive. It concludes by outlining a theory of the latter. (shrink)

I believe that the notion of epistemic transparency does play an important role in our ordinary conception of mental content and I want to say what that role is. Unfortunately, the task is a large one; here I am able only to begin on its outline. I shall proceed somewhat indirectly, beginning with a discussion of externalist conceptions of mental content. I shall show that such conceptions violate epistemic transparency to an extent that has not been fully appreciated. Subsequently, I (...) shall look at the implications of this violation and at the reconstructive project that a rejection of transparency entails. I am inclined to think it unlikely that we will get a conception of propositional content that underwrites epistemic transparency. But I am concerned that we have not fully appreciated the role that transparency currently plays and the work that would need to be done were we to discard it. (shrink)

The question I want to look at in this paper is this: To what extent does an externalist conception of mental content threaten our ability to know the contents of our thoughts? I shall argue that, in an important sense, externalism is inconsistent with the thesis that we have authoritative first-person knowledge of thought content: in particular, I shall argue, it is inconsistent with the thesis that our thought contents are epistemically transparent to us. I shall further argue that this (...) is true in a sense that falsifies another important and traditionally fundamental view —that we can detect a priori whether our inferences are logically valid or not. I shall leave for another occasion the question whether these results reflect badly on epistemic transparency or on externalism. (shrink)

The widespread effects of the coronavirus disease 2019 (COVID-19) pandemic have negatively impacted upon many athletes’ mental health and increased reports of depression as well as symptoms of anxiety. Disruptions to training and competition schedules can induce athletes’ emotional distress, while concomitant government-imposed restrictions (e.g., social isolation, quarantines) reduce the availability of athletes’ social and emotional support. Written Emotional Disclosure (WED) has been used extensively in a variety of settings with diverse populations as a means to promote emotional processing. The (...) expressive writing protocol has been used to a limited extent in the context of sport and predominantly in support of athletes’ emotional processing during injury rehabilitation. We propose that WED offers an evidence-based treatment that can promote athletes’ mental health and support their return to competition. Research exploring the efficacy of the expressive writing protocol highlights a number of theoretical models underpinning the positive effects of WED; we outline how each of these potential mechanisms can address the multidimensional complexity of the challenging circumstances arising from the COVID-19 pandemic (e.g., loss of earnings, returning to training and competition). Considerations and strategies for using WED to support athletes during the COVID-19 pandemic are presented. (shrink)

The core idea seems clear enough. To say of something that it is socially constructed is to emphasize its dependence on contingent aspects of our social selves. It is to say: This thing could not have existed had we not built it; and we need not have built it at all, at least not in its present form. Had we been a different kind of society, had we had different needs, values, or interests, we might well have built a different (...) kind of thing, or built this one differently. The inevitable contrast is with a naturally existing object, something that exists independently of us and which we did not have a hand in shaping. (shrink)

In the last several years anthropology has developed a mathematical theory1 which now has foundations almost as broad as the field of anthropology itself.2 This breadth includes works ranging from population genetics and demographic modeling to theories of social organization or even of mythological structures.3 In the present article we present elaborations of aspects of the theory as so far developed4 and discuss the significance of this new work for the possible solution of additional problems of interest. In particular we (...) refer both to the possibility of breaking barriers between fields of anthropology5 and also to the generality of the mathematics as such. (shrink)

14 essays which examine the efforts of Socrates' associates to preserve his speeches for posterity. The papers place particular emphasis on the non-Platonic tradition.

In this article, Whitehead's transition from a Philosophy of Evolution to a Philosophy of Organism is studied primarily on the basis of the evidence provided by the first two volumes of The Harvard Lectures of Alfred North Whitehead, especially the second volume that deals with the period 1925–1927 and that is subtitled General Metaphysical Problems of Science.

This is a critical discussion of Jerry Fodor and Ernie Lepore's "Holism". The paper questions the existence of a slippery slope from some inferential liaisons are constitutive of meaning' to all inferential liaisons are constitutive of meaning'. "Interalia", it defends the existence of an analytic/synthetic distinction.

Samuelson's text was first published in 1948, and it immediately became the authority for the principles of economics courses. The book continues to be the standard-bearer for principles courses, and this revision continues to be a clear, accurate, and interesting introduction to modern economics principles. Bill Nordhaus is now the primary author of this text, and he has revised the book to be as current and relevant as ever.

Reply to Schiffer's comment on Externalism and Inference.

This paper argues that Devitt’s arguments in "Transcendentalism About Content" don’t show how to answer the challenge I laid down in "Status Of Content". I proceed as follows. I begin by looking at why I didn’t formulate content eliminativism in the way that Devitt does, and why I did formulate it as the thesis of “content irrealism.” I then show in detail why his criticisms are off-target.

This collection of newly commissioned essays, edited by NYU philosophers Paul Boghossian and Christopher Peacocke, resumes the current surge of interest in the proper explication of the notion of a priori. The authors discuss the relations of the a priori to the notions of definition, meaning, justification, and ontology, explore how the concept figured historically in the philosophies of Leibniz, Kant, Frege, and Wittgenstein, and address its role in the contemporary philosophies of logic, mathematics, mind, and science. The editors’ (...) Introduction familiarizes the reader with the issues that are to be explored in detail in later parts of the anthology. (shrink)

Unlike the relativistic theses drawn from physics, normative relativisms involve relativization not to frames of reference but to something like our standards, standards that we have to be able to think of ourselves as endorsing or accepting. Th us, moral facts are to be relativized to moral standards and epistemic facts to epistemic standards. But a moral standard in this sense would appear to be just a general moral proposition and an epistemic standard just a general epistemic proposition. Pulling off (...) either relativism, then, requires not just relativizing the facts in the domain in question to the relevant standards; it requires taking a non-absolutist view of the standards themselves. Otherwise a commitment to absolute truths in the domain in question will show up in one’s attitude towards the standards themselves. But it is very hard to see how to take a genuinely non-absolutist attitude towards the standards themselves. That, in essence, is the difficulty for a relativistic view of a normative domain that I tried to develop in Chapter 6 of Fear of Knowledge. In their commentaries, Gideon Rosen and Ram Neta come up with ingenious ways of attempting to circumvent that difficulty. In my reply, I try to explain why I don’t believe they succeed. (shrink)

The fact that we can hear a particular passage of music as expressing a “tranquil gratitude” is a central aspect of the phenomenology of musical experience; without it we would be hard pressed to explain how purely instrumental music could move us in the way that it does. The trouble, here as so often elsewhere in philosophy, is that what seems necessary also seems impossible: for how could a mere series of nonlinguistic sounds, however lovely, express a state of mind? (...) One of the central tasks of the philosophy of music is to remove this mystery.... (shrink)